tracker

Table of Contents for Stem Cell Therapies and Regenerative Medicine: Current Applications and Future Possibilities



Paper - USD 3950.00  
Single-user PDF - USD 4542.50  


TABLE OF CONTENTS

INTRODUCTION

XVI

REASON FOR DOING THE STUDY

XVI

STUDY GOAL AND OBJECTIVES

XVI

CONTRIBUTIONS OF THE STUDY AND FOR WHOM

XVII

SCOPE AND FORMAT

XVII

METHODOLOGY AND INFORMATION SOURCES

XVIII

ANALYST'S CREDENTIALS

XVIII

OTHER RELEVANT BCC REPORTS AND PUBLICATIONS

XIX

BCC ONLINE SERVICES

XX

DISCLAIMER

XX

SUMMARY

XXI

Summary Table:
GLOBAL FORECAST OF REVENUES FOR STEM CELL AND CYTOKINE THERAPIES IN REGENERATIVE MEDICINE, THROUGH 2010 ($ BILLIONS)

XXII

Summary Figure:
GLOBAL FORECAST OF REVENUES FOR STEM CELL AND CYTOKINE THERAPIES IN REGENERATIVE MEDICINE, 2003-2010 ($ BILLIONS)

XXIII

OVERVIEW

1

Table 1 PERCENT OF PERSONS USING PRESCRIPTION DRUGS IN THE PAST MONTH IN THE U.S., 1999-2000

1

GROWTH FACTORS AND CYTOKINES

1

Table 2 SELECTED CYTOKINES OR GROWTH FACTORS RELEVANT TO REGENERATIVE MEDICINE

2

Table 2 (CONTINUED)

3

STEM AND PROGENITOR CELLS

3

WORLDWIDE MARKETS FOR REGENERATIVE MEDICINE

4

Table 3 LEADING CAUSES OF DEATH IN THE U.S., 2001

5

Table 4 PREVALENCE OF MEDICAL CONDITIONS IN THE U.S. WITH POTENTIAL CELL THERAPIES

6

Table 5 AGING OF THE U.S. POPULATION

6

CELL THERAPIES AS A SUBSTITUTE FOR TRANSPLANTS

7

THE U.S. MARKET VERSUS THE REST OF THE WORLD

7

The U.S. Market versus the (Continued)

8

Table 6 POPULATION OF COUNTRIES OF THE EUROPEAN UNION, 2003

9

DISTRIBUTION OF REVENUES AND EFFORT

10

TYPES OF STEM OR PROGENITOR CELLS

11

Table 7 DESCENDANTS OF THE HUMAN MESENCHYMAL STEM CELL

12

Autologous Cells

13

Allogeneic Cells

14

UMBILICAL CORD BLOOD

14

Table 8 A PARTIAL LIST OF DISEASES TREATED USING CORD BLOOD STEM CELLS

15

EMBRYONIC STEM CELLS

16

Embryonic Stem Cells (Continued)

17

Table 9 DERIVATION OF BODY TISSUE TYPES FROM GERM LAYERS

18

Table 10 CELL TYPES DERIVED FROM EMBRYONIC STEM CELLS IN VITRO

18

Table 10 (CONTINUED)

19

Identification of Stem Cells

19

Table 11 MARKERS OF PLURIPOTENT CELLS IN MOUSE, MAN, AND MONKEY

20

Therapeutic Cloning

20

Therapeutic Cloning (Continued)

21

Utility of ES Cells

22

Ethical Considerations

23

Position of the Catholic Church

24

Position of the National Academy of Sciences

25

Politics and Funding for Embryonic Stem Cell Research

26

Politics and Funding for Embryonic Continued)

27

NIH Guidelines

28

NIH Guidelines (Continued)

29

Table 12 EMBRYONIC STEM CELL LINES THAT MEET NIH FUNDING REQUIREMENTS, WHICH ARE AVAILABLE FOR SHIPPING

30

Patents

30

GERM CELLS

31

WHAT MAKES A STEM CELL A STEM CELL?

31

CELL-BASED GENE THERAPY

32

U.S. REGULATION

33

DEVICES

33

Table 13 FOOD AND DRUG ADMINISTRATION BODIES INVOLVED IN IMPLANT REGULATION

34

BIOLOGICALS

35

Biologicals (Continued)

36

ORPHAN PRODUCT STATUS

37

INTERNATIONAL ISSUES

37

OFFSHORE CELL-THERAPY TREATMENTS

38

OFFSHORE CELL-THERAPY TREATMENTS (CONTINUED)

39

APPLICATIONS FOR PROGENITOR CELL THERAPIES

40

APPLICATIONS OF REGENERATIVE MEDICINE FOR BLOOD AND THE IMMUNE SYSTEM

40

Figure 1 HEMATOPOIESIS

41

APPLICATIONS OF REGENERATIVE CONTINUED)

42

Table 14 A PARTIAL LIST OF DISEASES TREATED WITH HEMATOPOIETIC STEM CELLS

43

Table 14 (CONTINUED)

44

HARVESTING HEMATOPOIETIC STEM CELLS

44

Bone Marrow

44

Peripheral Blood Progenitor Cell Collection

45

Umbilical Cord Blood

46

Drug-Resistant Hematopoietic Stem Cells

46

PRODUCTS AND SERVICES IN SUPPORT OF HEMATOPOIETIC STEM CELL TRANSFERS

47

Table 15 COMMERCIAL OPPORTUNITIES FOR HEMATOPOIETIC STEM CELL TRANSPLANTATION

48

CYTOKINES FOR STEM CELL THERAPY

49

Table 16 APPROVED BIOPHARMACEUTICALS FOR THE REGENERATION OF BLOOD AND IMMUNE CELLS AFTER CHEMOTHERAPY

50

G-CSF and GM-CSF

50

AMD3100

51

Erythropoietins

51

MARKET OPPORTUNITIES FOR REGENERATIVE CYTOKINES

52

Table 17 SALES OF THERAPEUTIC REGENERATIVE CYTOKINES FOR BLOOD AND IMMUNE DISEASES, THROUGH 2010 ($ MILLIONS)

53

Figure 2 SALES OF THERAPEUTIC REGENERATIVE CYTOKINES FOR BLOOD AND IMMUNE DISEASES, 2003-2010 ($ MILLIONS)

53

HARVESTING AND STORAGE OF UMBILICAL CORD BLOOD

54

Table 18 COMMERCIAL UMBILICAL CORD BLOOD STORAGE COMPANIES

55

Market Opportunities for Umbilical Cord Blood Storage

56

Table 19 FEES CHARGED BY MAJOR UMBILICAL CORD BLOOD BANKS, 2005 ($)

57

Table 20 WORLDWIDE REVENUES FROM CORD BLOOD HARVEST AND STORAGE, THROUGH 2010 ($ MILLIONS)

58

Figure 3 WORLDWIDE REVENUES FROM CORD BLOOD HARVEST AND STORAGE, 2003-2010 ($ MILLIONS)

58

EXPANSION OF STEM CELLS

58

Expansion of Stem Cells (Continued)

59

Market Opportunities for Stem Cell Expansion.

60

Table 21 WORLDWIDE REVENUES FROM EXPANSION AND CULTURE OF THERAPEUTIC STEM CELLS, THROUGH 2010 ($ MILLIONS)

60

Figure 4 WORLDWIDE REVENUES FROM EXPANSION AND CULTURE OF THERAPEUTIC STEM CELLS, 2003-2010 ($ MILLIONS)

61

GRAFT-VERSUS-HOST DISEASE

61

IMMUNE DEFICIENCIES

62

Acquired Immunodeficiency Syndrome

63

Table 22 AQUIRED IMMONDEFICIENCY CASES REPORTED BY YEAR IN THE U.S., 1985-2003

64

Natural Resistance

64

Current Therapies for AIDS

65

Progenitor Cell Therapies for AIDS

65

Market Opportunities for AIDS Therapies

66

Table 23 SIZE OF THE AIDS/HIV EPIDEMIC

66

SUMMARY: BLOOD AND IMMUNE DISEASES

67

Table 24 GLOBAL FORECAST OF REVENUES FOR BLOOD AND IMMUNE DISEASES ($ MILLIONS)

67

Table 5 GLOBAL FORECAST OF REVENUES FOR BLOOD AND IMMUNE DISEASES ($ MILLIONS)

68

SKIN

68

SKIN CELL PROGENITORS

69

BURNS

69

ULCERS

70

ULCERS (CONTINUED)

71

MARKET OPPORTUNITIES FOR SKIN CELL THERAPIES

72

MARKET OPPORTUNITIES FOR SKIN CELL THERAPIES (CONTINUED)

73

Table 25 GLOBAL FORECAST OF REVENUES FOR REGENERATIVE WOUND THERAPY PRODUCTS, THROUGH 2010 ($ MILLIONS)

74

Figure 6 GLOBAL FORECAST OF REVENUES FOR REGENERATIVE WOUND THERAPY PRODUCTS, 2003-2010 ($ MILLIONS)

74

BONE

74

BONE FRACTURES

75

Bone Metabolism

76

Current Therapies

77

Cell Therapies for Bone Fractures

77

Growth Factors and Morphogenic Proteins

78

Table 26 GROWTH FACTOR PRODUCTS FOR BONE HEALING

79

Table 27 GROWTH FACTORS DEVELOPED BUT NOT YET APPROVED FOR BONE INDICATIONS

80

Market Opportunities for Regenerative Therapies for Fractures and Spinal Fusions

80

Table 28 SPINAL FUSION DATA, U.S. 1998-2002 ($)

81

Table 29 NUMBER OF LOWER LEG FRACTURE, 1998-2002

81

Table 30 GLOBAL FORECAST OF REVENUES FOR REGENERATIVE THERAPIES FOR SPINAL FUSIONS AND BONE FRACTURES ($ MILLIONS)

82

Figure 7 GLOBAL FORECAST OF REVENUES FOR REGENERATIVE THERAPIES FOR SPINAL FUSIONS AND BONE FRACTURES ($ MILLIONS)

82

CARTILAGE

83

Table 31 PRODUCTS FOR REGENERATIVE CARTILAGE REPAIR

83

MENISCUS REPAIR

83

INJURIES OF THE KNEE

84

INTERVERTEBRAL DISC REGENERATION

85

MARKETS FOR CARTILAGE REPAIR

85

Table 32 GLOBAL FORECAST OF SALES OF CELL THERAPY PRODUCTS TO REPAIR CARTILAGE, THROUGH 2010 ($ MILLIONS)

86

Figure 8 GLOBAL FORECAST OF SALES OF CELL THERAPY PRODUCTS TO REPAIR CARTILAGE, 2003-2010 ($ MILLIONS)

87

CARDIOVASCULAR SYSTEM

87

CONGESTIVE HEART FAILURE

88

Current Therapies

88

CORONARY HEART DISEASE

89

Current Therapies

89

CELL THERAPIES FOR CHF OR CORONARY DISEASE

89

Cell Therapies for CHF or Coronary Disease (Continued)

90

Cell Therapies for CHF or Coronary Disease (Continued)

91

CARDIAC ARRYTHMIA

92

Current Therapy

92

Cell Therapies

93

MARKET OPPORTUNITIES FOR CARDIOVASCULAR CELL THERAPIES

93

Table 33 PREVALENCE OF HEART DISEASE IN U.S. ADULTS (18 YEARS AND OVER), 2002 (THOUSAND)

94

TEETH

95

HAIR

95

BRAIN AND NERVOUS SYSTEM

96

NEURAL STEM CELLS

97

LYSOSOMAL STORAGE DISEASES

97

DISORDERS OF THE MYELIN SHEATH

98

SPINAL CORD INJURY

99

Spinal Cord Injury (Continued)

100

STROKE

101

Table 34 DEATH RATES PER 100,000 FROM CEREBROVASCULAR DISEASE (STROKE) IN THE U.S., 1960 AND 2002

102

PARKINSON'S DISEASE

103

Cell Therapies

103

Cell Therapies (Continued)

104

The Market Opportunities for Regenerative Treatments to Treat Neural Disease

105

EYES

105

EYES (CONTINUED)

106

Market Opportunities

107

LIVER

108

HUMAN CELL THERAPIES

109

Human Cell Therapies (Continued)

110

Markets for Regenerative Therapies for the Liver

111

KIDNEY

111

Potential Cell Therapies for Kidney Disease

112

Market Opportunities for Regenerative Kidney Therapies

113

DIABETES

113

Table 35 GLOBAL PREVALENCE OF DIABETES IN EUROPE, AGES 20 TO 79 2003 AND 2025 (THOUSANDS)

114

COMPLICATIONS OF DIABETES

115

Current Treatments

115

Edmonton Protocol

116

STEM CELL THERAPIES

116

Market Opportunities for Regenerative Diabetes Therapies

117

REPRODUCTIVE MEDICINE

118

MARKET OPPORTUNITIES FOR OOCYTE CRYOPRESERVATION

119

Table 36 GLOBAL FORECAST OF REVENUES DERIVED FROM OOCYTE STORAGE, THROUGH 2010 ($ MILLION)

120

Figure 9 GLOBAL FORECAST OF REVENUES DERIVED FROM OOCYTE STORAGE, 2003-2010 ($ MILLION)

120

PRODUCTS USED IN CELL THERAPY AND REGENERATIVE MEDICINE

121

PRODUCTS USED FOR AMPLIFYING, CULTURING, OR TRANSFERRING STEM CELLS

121

AASTROMREPLICELL SYSTEM

121

MYOCATH PERCUTANEOUS DELIVERY SYSTEM

122

PLURIX BIOREACTOR SYSTEM

123

CYTOMATRIX

123

CYTOKINES AND GROWTH FACTORS

124

Table 37 CYTOKINES AND GROWTH FACTORS IN REGENERATIVE MEDICINE

124

AMD3100

125

ARANESP

125

BMP-7

126

CHRYSALIN

126

CTCE-0214

126

CYT 99 007

127

EPOGEN/PROCRIT

127

INFUSE/INDUCTOS

128

NEULASTA

128

NEUMEGA

129

NEUPOGEN

129

OP-1

130

REGRANEX GEL

131

THYMOSIN BETA FOUR

131

TUMOR GROWTH FACTOR ALPHA

132

LIVING CELL THERAPIES

132

HEMATOPOIETIC AND IMMUNE CELL THERAPIES

133

Table 38 LIVING BLOOD AND IMMUNE CELL THERAPEUTIC PRODUCTS IN DEVELOPMENT

133

Highly Purified Hematopoietic Stem Cells

134

HGTV-43

134

MP Cells

135

Procord

136

SKIN

136

Table 39 LIVING SKIN EQUIVALENTS USED THERAPEUTICALLY

136

Apligraf

137

Dermagraft

137

EpiCel

138

Hyalograft 3D

138

Laserskin Autograft

138

OrCel

139

CARTILAGE

139

Table 40 LIVING-CELL PRODUCTS USED THERAPEUTICALLY TO REPAIR CARTILAGE

139

Carticel

139

Cartilink

140

Chondrogen

141

Co.Don Chondrotransplant

141

Co.Don Chondrotransplant DISC

141

Hyalograft C

142

ICX-PRO

142

ICX-SKN

142

NEURAL STEM CELLS

143

HuCNS-SC

143

MUSCLE

143

Table 41 MUSCLE CELLS USED AS THERAPEUTIC PRODUCTS

143

Biopace

143

MyoCell

144

Myocell VT

144

Provacel

145

OTHER MESENCHYMAL CELLS

145

Prochymal

145

Tissue Repair Cells - Aastrom Bioscience

146

PANCREAS

146

IxSC-1

146

KIDNEY

147

Renal Assist Device

147

STEM CELL STORAGE

147

BIOARCHIVE STEM CELL SYSTEM

147

CCEL CELLULAR STORAGE FREEZER

148

STRUCTURE OF THE INDUSTRY

149

CYTOKINE AND GROWTH FACTOR COMPANIES

149

Table 42 COMPANIES SUPPLYING APPROVED CYTOKINE OR GROWTH FACTOR THERAPIES

149

MARKET SHARES OF CYTOKINE AND GROWTH FACTOR COMPANIES

150

Table 43 RANKINGS AND MARKET SHARES OF COMPANIES FOR CYTOKINES AND GROWTH FACTORS IN 2004 (REVENUES)

150

PRODUCTS UNDER DEVELOPMENT

150

Table 44 COMPANIES DEVELOPING GROWTH FACTOR OR CYTOKINE PRODUCTS

151

UMBILICAL CORD STEM CELL COMPANIES

151

Table 45 2004 WORLDWIDE MARKET RANKINGS FOR UMBILICAL CORD STEM CELL STORAGE COMPANIES

151

CELL THERAPY COMPANIES

152

Table 46 FOCUS OF STEM AND PROGENITOR CELL THERAPY COMPANIES

152

Table 46 (CONTINUED)

153

Table 46 (CONTINUED)

154

PATENTS

154

PATENTS (CONTINUED)

155

Table 47 U.S. PATENT APPLICATIONS FROM JANUARY 1, 2001 THROUGH SEPTEMBER 8, 2005, WITH SELECTED STEM CELL SEARCH TERMS

156

Table 48 SELECTED U.S. STEM CELL PATENTS ISSUED BETWEEN JANUARY 2002 AND SEPTEMBER 2005

157

Table 48 (CONTINUED)

158

Table 48 (CONTINUED)

159

Table 48 (CONTINUED)

160

ATTRITION

160

Table 49 DISAPPEARING NAMES IN REGENERATIVE MEDICINE

161

COMPANY PROFILES

162

AASTROM BIOSCIENCES

162

ADERANS RESEARCH INSTITUTE

162

ADVANCED CELL TECHNOLOGY

163

ADVANCED CELL THERAPEUTICS

164

AMGEN

164

ANORMED

165

ATHERSYS

165

BAXTER INTL.

166

BEFUTUR BIOTECHNOLOGIES

166

BIOHEART

167

BIOMATRIX SCIENTIFIC GROUP

168

BIOTISSUE, INC.

168

BIOTISSUE TECHNOLOGIES AG

168

BRAINSTORM CELL THERAPEUTICS

169

CELLARTIS

170

CELL BASED DELIVERY

170

CELLERANT THERAPEUTICS

171

CELLRESEARCH CORP.

171

CELLULAR DYNAMICS

172

CHEMOKINE THERAPEUTICS

172

CO.DON AG

173

CORCELL

173

CORD BLOOD AMERICA

173

CORD BLOOD REGISTRY

174

CYGENICS

174

CORDLIFE PTE, LTD./ CELL SCIENCES PTE, LTD.

174

CYTOMATRIX

175

CRYO-CELL INTL.

175

CYTHERA

176

CYTORI THERAPEUTICS

176

DENTIGENIX, INC.

177

ENCELLE

177

ENZO BIOCHEM

178

EXTENDFERTILITY

179

FIDIA FARMACEUTICI SPA

179

FREZER, INC.

179

GENZYME BIOSURGERY

180

GENVEC

181

GERON

181

HISTOSTEM

182

INTERCYTEX

182

INTERFACE BIOTECH A/S

183

ISLET TECHNOLOGY

183

ISTO TECHNOLOGIES

184

IXION BIOTECHNOLOGY

185

KALEIDOS PHARMACEUTICAL

185

JOHNSON & JOHNSON

186

LIFEBANK CRYOGENICS

186

MEDRA

187

MESOBLAST, LTD.

187

MILTENYI BIOTEC GMBH

188

MORPHOGENESIS

188

NEOSTEM

189

NEPHROS THERAPEUTICS

189

NEURALSTEM BIOPHARMACEUTICALS

190

NEURONYX

190

NOVARTIS INTERNATIONAL AG

191

NS GENE A/S

191

ODONTIS

192

ORGANOGENESIS

192

ORTEC INTL.

193

ORTHOLOGIC

193

OSIRIS THERAPEUTICS

194

PHARMA FRONTIERS

194

PHARMASTEM THERAPEUTICS

195

PLURISTEM LIFE SYSTEMS

195

PRIMEGEN BIOTECH, LLC

196

PROGENITOR CELL THERAPY

196

PRONEURON BIOTECHNOLOGIES

197

REGENERX BIOPHARMACEUTICALS

197

RENEURON

198

SANERON CCEL THERAPEUTICS, INC.

198

STEMCELLS, INC.

199

STEMCELL PHARMA, INC.

199

STEM CELL SCIENCES

200

STEM CELL THERAPEUTICS CORP.

200

STEM CELL THERAPY INTL.

201

THERMOGENESIS

202

TISSERA

202

U.S. BIODEFENSE, INC.

202

VESTA THERAPEUTICS

203

VIACELL

203

WICELL RESEARCH INSTITUTE

204

APPENDIX

205

GLOSSARY OF TERMS AND ABBREVIATIONS

205

GLOSSARY OF TERMS AND ABBREVIATIONS (CONTINUED)

206

GLOSSARY OF TERMS AND ABBREVIATIONS (CONTINUED)

207

GLOSSARY OF TERMS AND ABBREVIATIONS (CONTINUED)

208

GLOSSARY OF TERMS AND ABBREVIATIONS (CONTINUED)

209

GLOSSARY OF TERMS AND ABBREVIATIONS (CONTINUED)

210

GLOSSARY OF TERMS AND ABBREVIATIONS (CONTINUED)

211

GLOSSARY OF TERMS AND ABBREVIATIONS (CONTINUED)

212

GLOSSARY OF TERMS AND ABBREVIATIONS (CONTINUED)

213
   

LIST OF TABLES

 

Summary Table:
GLOBAL FORECAST OF REVENUES FOR STEM CELL AND CYTOKINE THERAPIES IN REGENERATIVE MEDICINE, THROUGH 2010 ($ BILLIONS)

XXII

Table 1 PERCENT OF PERSONS USING PRESCRIPTION DRUGS IN THE PAST MONTH IN THE U.S., 1999-2000

1

Table 2 SELECTED CYTOKINES OR GROWTH FACTORS RELEVANT TO REGENERATIVE MEDICINE

2

Table 3 LEADING CAUSES OF DEATH IN THE U.S., 2001

5

Table 4 PREVALENCE OF MEDICAL CONDITIONS I

CMS, P&A House, Alma Road, Chesham, Bucks. HP5 3HB, UK
Tel:     +44 (0)1494 771734
Fax:   +44 (0)1494 778994
e-mail: jenniferc@cmsinfo.com


copyright © 2005 all rights reserved

For more information about us, visit CMSinfo.

footer bar